Four fire engines and around 25 firefighters tackled a fire at a block of flats on Cadogan Road in Plumstead.
Part of a split level fifth floor maisonette was damaged by the fire. There were no reports of any injuries.
Control Officers took the first of three calls at 0054 and mobilised crews from Plumstead, Erith and Eltham fire stations to the scene. The incident was over for firefighters at 0148.
The cause of the fire is under investigation.