Ten fire engines and around 70 firefighters were called to flooding between Dace Road and Wick Lane in Bow.
A canal burst its banks, causing water to flood an area of around 10 acres and affecting nearby properties. Firefighters carried out welfare checks on around 100 people who were able to remain in their unaffected properties, whilst approximately 50 people were led to safety.
Station Commander Dan Capon, who was at the scene, said: "Firefighters worked through the night to ensure the scene was safe and evacuated a number of people from surrounding buildings.
"We urged people to avoid the area where possible. Remember - if your property is affected by flooding, move to a higher level where possible. If you are in immediate danger, call 999. Follow the advice of the operator."
The Brigade was called at 2216 and the incident was over for firefighters by 0150. Fire crews from Bethnal Green, Leytonstone, Millwall, Plaistow, Islington and surrounding fire stations attended the scene.
What to do when there is a flood
The Brigade has a range of equipment which can be used to help rescue people trapped by flood water, pump water away and protect properties.
Fire rescue units are equipped with water rescue equipment such as inflatable rescue boats and the Brigade has specialist flood response kits, each containing rigid flood rescue boats and paddles and rigid floating pontoons, and flood barriers. They also contain protective dry suits and boots to be worn by fire crews when rescuing people from flooded areas.