Four fire engines and around 25 firefighters tackled a boat fire on Alfred Road in Maida Vale.
One canal boat was destroyed by fire. There are no reports of any injuries.
The Brigade's 999 Control Officers took over 15 calls to the fire. The Brigade was first called at 0920 and the fire was under control by 1020. Crews from Willesden, Park Royal, Chiswick and Edmonton fire stations attended the scene.
The cause of the fire is under investigation.