Five fire engines and around 30 firefighters attended a fire on Oval Road North in Dagenham.
Half of the ground floor of a two-storey mid-terraced house was damaged by fire. One man was rescued from the house by firefighters but was sadly pronounced dead at the scene by London Ambulance Service crews.
The Brigade was called at 1736 and the fire was extinguished by 1842. Crews from Dagenham, Barking and Shadwell fire stations attended the scene.
The cause of the fire is under investigation by the Brigade and Metropolitan Police.