Four fire engines and around 25 firefighters tackled a fire on Acre Lane in Brixton.
Part of a takeaway restaurant, with homes above, was damaged by fire. There have been no reports of any injuries at this time.
The fire is believed to have been caused by the accidental ignition of hot oil.
A London Fire Brigade spokesperson said: ""Fires are more likely to start in the kitchen than any other room in the home.
"Cooking should never be left unattended on the hob or grill - if you have to leave the kitchen, turn off the heat. Chip pans and cooking with hot oil can be really dangerous and the risk increases when you start frying food more than once. All it can take is for you to become distracted for a few seconds and your cooking oil can quickly go up in flames.”
The Brigade's Control Officers took the first of five calls about the fire at 1241 and the fire was extinguished by 1338. Crews from Clapham, Norbury, West Norwood and Dowgate fire stations attended the scene.