Four fire engines and around 25 firefighters tackled a fire at a house converted into flats on Redcliffe Gardens in Earl's Court.
One flat on the first floor of the five-storey building was destroyed by fire. Four further flats on the first, second, and third floors were partially damaged by fire. Three adult men suffering smoke inhalation were treated on-scene by London Ambulance Service.
The Brigade was called at 0627 and the fire was under control by 0934. Crews from Kensington, Hammersmith, Soho and Fulham fire stations attended the scene.
The cause of the fire is under investigation.