Four fire engines and around 25 firefighters tackled a fire at a garage on New Cross Road in New Cross.
A detached garage was destroyed by the fire. There were no reports of any injuries.
Control Officers took the first of 11 calls regarding the fire at 0213 and the incident was over for firefighters at 0416. Crews from Greenwich, Deptford, Lewisham and Peckham fire stations attended the scene.
The cause of the fire is under investigation.