Ten fire engines and around 70 firefighters tackled a flat fire on Rymill Street in North Woolwich.
Most of a three-roomed flat on the 10th floor was damaged by fire. Firefighters led four people to safety, whilst others remained in their unaffected flats. Five people were taken to hospital by London Ambulance Service crews. Around 100 residents were taken to a local rest centre.
The Brigade's 999 Control Officers took almost 30 calls to the blaze.
The Brigade was called at 2232 and the fire was under control by 2350. Fire crews from Plaistow, Barking, East Ham, Poplar and surrounding fire stations attended the scene.
The cause of the fire is under investigation.