Eight fire engines and around 60 firefighters tackled a fire at a mid-terraced house on Osborne Grove in Walthamstow.
The roof of the house was destroyed by fire along with most of the first floor. Part of the ground floor was also damaged. There have been no reports of any injuries at this time.
One of the Brigade's 32-metre turntable ladders was used at the scene as a water tower to help fight the fire from above.
Road closures were in place from the junction of Mission Grove and Palmerston Road through to Buxton Road whilst the incident was ongoing.
Control Officers took 22 calls regarding the blaze. The first was received at 2207 and the fire was under control by 0007. Crews from Walthamstow, Leyton, Tottenham and surrounding fire stations attended the scene.
The cause of the fire is under investigation.