Firefighters attended a road traffic collision on New Oxford Street in Soho.
One double decker bus collided into the front of a mid-terraced gallery and office building. One man left the bus before the Brigade's arrival and was taken to hospital by London Ambulance Service crews. There are no further reports of injuries.
Firefighters evacuated around 200 people from the property using the building's rear entrance. Road closures remain in place and people are advised to avoid the area at this time.
A structural engineer has declared the building safe with no further concerns.
The Brigade was called at 1011 and the incident was over for firefighters at 1302. Two fire engines and two fire and rescue units from Soho, Euston and Battersea fire stations attended the scene.