Eight fire engines and around 60 firefighters tackled a fire at a block of flats above a restaurant on Peckham Park Road in Peckham.
A two-roomed flat on the second floor was destroyed by fire. Two people suffering from smoke inhalation were taken to hospital by London Ambulance Service crews.
One of the Brigade's 64-metre turntable ladders was used as a water tower to fight the fire from above.
Control Officers took 15 calls regarding the blaze. The first call was received at 1311 and the fire was under control by 1417. Firefighters from Old Kent Road, New Cross, Peckham and surrounding fire stations attended the scene.
The cause of the fire is under investigation by the Brigade and Metropolitan Police Services.