Six fire engines and around 40 firefighters tackled a fire at a block of maisonettes on Dawes Street in Walworth.
Part of a maisonette split between the first and ground floors was damaged by the fire. There are currently no reports of any injuries.
Control Officers received the call at 2352 and mobilised firefighters from Old Kent Road, Peckham, Dockhead and surrounding fire stations to the scene. The fire was under control by 0055.
The cause of the fire is under investigation.