Eight fire engines and around 60 firefighters tackled a fire at a residential block of flats on Mizzen Street in Barking.
A four-roomed flat on the sixth floor of the seven-storey building was mostly destroyed by fire. Around 50 people were led to safety from the property by firefighters, with one adult man and one adult woman taken to hospital by London Ambulance Service.
The Brigade's 999 Control Officers took over 10 calls to this incident, with the first call received at 0046. Control Officers mobilised crews from Barking, East Ham, Plaistow and surrounding fire stations to the scene. The fire was under control by 0148.
The cause of the fire is believed to be accidental and is under investigation.