Four fire engines and around 25 firefighters attended a fire near Leyland Road in Lewisham.
A derelict maisonette flat was damaged by fire. There were no reports of any injuries.
The Brigade's Control Officers received around five calls about the fire. The Brigade was called at 2114 and Control Officers mobilised crews from Lee Green, Lewisham, Eltham and East Greenwich fire stations to the scene. The fire was extinguished by 2222.
The cause of the fire is under investigation by the Brigade and Metropolitan Police.