Twenty fire engines and around 125 firefighters tackled a fire at a hotel on Chiltern Street in Marylebone.
The fire started in a ground floor restaurant and spread to the roof of the four-storey hotel via the ducting. The roof and third floor were destroyed by the fire. Around half of the second floor and a small part of the ground floor were damaged by the fire.
Assistant Commissioner Paul McCourt was the Incident Commander at the scene. He said: "Crews worked incredibly hard for over eight hours in arduous conditions. Presented with a complex fire in a historically significant building, formerly Manchester Square Fire Station, firefighters successfully contained the fire to one property, preventing it from spreading to neighbouring properties.
"Around 100 people evacuated the building before the Brigade arrived and thankfully there have been no reports of any injuries.
"Firefighters remained on scene overnight and into Saturday damping down hotspots.
"I would like to take this opportunity to thank our crews, Control Officers, fire safety officers and support staff who worked to resolve the incident."
Two 32-metre turntable ladders from Paddington and Soho Fire Stations were used at the scene as water towers to help fight the fire from above.
The Brigade's Drone Team were also deployed and assisted the Incident Commander with an aerial view of the fire.
In total, over 63 fire engines attended this incident, alongside 23 special appliances and 25 officers.
The Brigade's 999 Control Officers took the first of 13 calls at 1452 and deployed fire crews from Euston, Soho, Paddington, West Hampstead, Kensington, Chelsea, and surrounding fire stations. The incident was under control by 2007.
The fire is believed to have been accidental and was caused by burning wood falling from a pizza oven and igniting the void between the basement and ground floor.