Four fire engines and around 25 firefighters tackled a fire at a mid terraced house on Egerton Road in Wembley.
A small part of the roof was damaged and the first floor was destroyed by the fire. Five people left the building before the Brigade arrived. There were no reports of any injuries.
Control Officers took the first of seven calls at 0722 and mobilised crews from Wembley, Park Royal, Acton and Willesden fire stations to the scene. The incident was over for firefighters at 0917.
The cause of the fire is under investigation.